Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-β
Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrP C ) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A 2 (cPLA 2 ) to lipid rafts and activation of cPLA 2 . The...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-10-01
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| Series: | Journal of Experimental Neuroscience |
| Online Access: | https://doi.org/10.1177/1179069517733096 |