Nontargeted Metabolomics Reveals the Multilevel Response to Antibiotic Perturbations

Nontargeted Metabolomics Reveals the Multilevel Response to Antibiotic Perturbations

Microbes have shown a remarkable ability in evading the killing actions of antimicrobial agents, such that treatment of bacterial infections represents once more an urgent global challenge. Understanding the initial bacterial response to antimicrobials may reveal intrinsic tolerance mechanisms to an...

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Bibliographic Details
Main Authors: Mattia Zampieri, Michael Zimmermann, Manfred Claassen, Uwe Sauer
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
E. coli
antibiotic response
metabolomics
antibiotic tolerance
dTDP-rhamnose
ammonium imbalance
quinolones
chloramphenicol
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717304618

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http://www.sciencedirect.com/science/article/pii/S2211124717304618

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