Osthole Ameliorates Renal Fibrosis in Mice by Suppressing Fibroblast Activation and Epithelial-Mesenchymal Transition

Osthole Ameliorates Renal Fibrosis in Mice by Suppressing Fibroblast Activation and Epithelial-Mesenchymal Transition

Renal fibrosis is a common pathway of virtually all progressive kidney diseases. Osthole (OST, 7-Methoxy-8-(3-methylbut-2-enyl)-2-chromenone), a derivative of coumarin mainly found in plants of the Apiaceae family, has shown inhibitory effects on inflammation, oxidative stress, fibrosis and tumor pr...

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Bibliographic Details
Main Authors: Suping Zhang, Qian Huang, Xiaoxia Cai, Shan Jiang, Nan Xu, Qin Zhou, Xiaoyun Cao, Michael Hultström, Jiong Tian, En Yin Lai
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Physiology
Subjects:
osthole
fibroblast
EMT
inflammation
renal fibrosis
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01650/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01650/full

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