Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses.

Physiological induction of regulatory Qa-1-restricted CD8+ T cells triggered by endogenous CD4+ T cell responses.

T cell-dependent autoimmune diseases are characterized by the expansion of T cell clones that recognize immunodominant epitopes on the target antigen. As a consequence, for a given autoimmune disorder, pathogenic T cell clones express T cell receptors with a limited number of variable regions that d...

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Bibliographic Details
Main Authors: Aditi Varthaman, Marc Clement, Jamila Khallou-Laschet, Giulia Fornasa, Anh-Thu Gaston, Michael Dussiot, Giuseppina Caligiuri, Harvey Cantor, Srinivas Kaveri, Antonino Nicoletti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3124544?pdf=render

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http://europepmc.org/articles/PMC3124544?pdf=render

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