The KRAS/Lin28B axis maintains stemness of pancreatic cancer cells via the let‐7i/TET3 pathway

The KRAS/Lin28B axis maintains stemness of pancreatic cancer cells via the let‐7i/TET3 pathway

Increasing evidence demonstrates that Lin28B plays critical roles in numerous biological processes including cell proliferation and stemness maintenance. However, the molecular mechanisms underlying Lin28B nuclear translocation remain poorly understood. Here, we found for the first time that KRAS pr...

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Bibliographic Details
Main Authors: Yawen Liu, Dawei Wang, Meng Zhou, Hui Chen, Huizhi Wang, Jingyu Min, Jiaxi Chen, Shuhui Wu, Xiufan Ni, Youli Zhang, Aihua Gong, Min Xu
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Molecular Oncology
Subjects:
KRAS
let‐7
Lin28B
pancreatic cancer
TET3
Online Access:https://doi.org/10.1002/1878-0261.12836

Internet

https://doi.org/10.1002/1878-0261.12836

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