Chemical complementarity between immune receptors and cancer mutants, independent of antigen presentation protein binding, is associated with increased survival rates

Chemical complementarity between immune receptors and cancer mutants, independent of antigen presentation protein binding, is associated with increased survival rates

Uterine cancer has been associated with a T-cell immune response that leads to increased survival. Therefore, we used several bioinformatics approaches to explore specific interactions between T-cell receptor (TCR) and tumor mutant peptide sequences. Using endometrioid uterine cancer exome files fro...

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Bibliographic Details
Main Authors: Monica Hsiang, Boris I. Chobrutskiy, Michael Diaz, Taha I. Huda, Stefan Creadore, Saif Zaman, Konrad J. Cios, Etienne C. Gozlan, George Blanck
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Translational Oncology
Subjects:
uterine cancer immunogenomics
TCR-mutant amino acid complementarity scoring
complementarity determining region-3
Online Access:http://www.sciencedirect.com/science/article/pii/S1936523321000619

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http://www.sciencedirect.com/science/article/pii/S1936523321000619

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