Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells

Kinome-Wide siRNA Screening Identifies Src-Enhanced Resistance of Chemotherapeutic Drugs in Triple-Negative Breast Cancer Cells

Background: Chemotherapy is the main treatment for triple-negative breast cancer (TNBC), which lack molecular markers for diagnosis and therapy. Cancer cells activate chemoresistant pathways and lead to therapeutic failure for patients with TNBC. Several kinases have been identified as chemoresistan...

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Bibliographic Details
Main Authors: Yen-Dun Tony Tzeng, Pei-Feng Liu, Ju-Yueh Li, Li-Feng Liu, Soong-Yu Kuo, Chiao-Wei Hsieh, Cheng-Hsin Lee, Chih-Hsuan Wu, Michael Hsiao, Hong-Tai Chang, Chih-Wen Shu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Pharmacology
Subjects:
kinome
siRNA
high-throughput screening
Src kinase
chemoresistance
triple-negative breast cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01285/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01285/full

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