CFTR Activator Increases Intestinal Fluid Secretion and Normalizes Stool Output in a Mouse Model of ConstipationSummary

Background & Aims: Constipation is a common clinical problem that negatively impacts quality of life and is associated with significant health care costs. Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel is the primary pathway that drives fluid secret...

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Bibliographic Details
Main Authors: Onur Cil, Puay-Wah Phuan, Sujin Lee, Joseph Tan, Peter M. Haggie, Marc H. Levin, Liang Sun, Jay R. Thiagarajah, Tonghui Ma, Alan S. Verkman
Format: Article
Language:English
Published: Elsevier 2016-05-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X16000072