Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface

Reversal of axonal growth defects in an extraocular fibrosis model by engineering the kinesin–microtubule interface

How mutations in β3-tubulin cause axonal growth defects in congenital fibrosis of the extraocular muscles type 3 remains elusive. Minoura et al. develop a model system using recombinant human tubulin that demonstrates a link between tubulin mutation, impaired kinesin motility and axonal growth defec...

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Bibliographic Details
Main Authors: Itsushi Minoura, Hiroko Takazaki, Rie Ayukawa, Chihiro Saruta, You Hachikubo, Seiichi Uchimura, Tomonobu Hida, Hiroyuki Kamiguchi, Tomomi Shimogori, Etsuko Muto
Format: Article
Language:English
Published: Nature Publishing Group 2016-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms10058

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https://doi.org/10.1038/ncomms10058

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