HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury

Abstract Background In muscular dystrophy and old age, skeletal muscle repair is compromised leading to fibrosis and fatty tissue accumulation. Therefore, therapies that protect skeletal muscle or enhance repair would be valuable medical treatments. Hypoxia-inducible factors (HIFs) regulate gene tra...

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Bibliographic Details
Main Authors: Andrew N. Billin, Samuel E. Honeycutt, Alan V. McDougal, Jaclyn P. Kerr, Zhe Chen, Johannes M. Freudenberg, Deepak K. Rajpal, Guizhen Luo, Henning Fritz Kramer, Robert S. Geske, Frank Fang, Bert Yao, Richard V. Clark, John Lepore, Alex Cobitz, Ram Miller, Kazunori Nosaka, Aaron C. Hinken, Alan J. Russell
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Skeletal Muscle
Subjects:
Eccentric injury
HIF activation
Skeletal muscle
Prolyl hydroxylase
Protection
Online Access:http://link.springer.com/article/10.1186/s13395-018-0179-5

Internet

http://link.springer.com/article/10.1186/s13395-018-0179-5

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