Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

Efficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins

Giardia lamblia express a dense coat of variant-specific surface proteins (VSPs) on trophozoites that protects the parasite inside the host´s intestine. Here the authors show that stability and immunomodulatory properties of VSPs can be exploited to both protect and adjuvant vaccine antigens for ora...

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Bibliographic Details
Main Authors: Marianela C. Serradell, Lucía L. Rupil, Román A. Martino, César G. Prucca, Pedro G. Carranza, Alicia Saura, Elmer A. Fernández, Pablo R. Gargantini, Albano H. Tenaglia, Juan P. Petiti, Renata R. Tonelli, Nicolás Reinoso-Vizcaino, José Echenique, Luciana Berod, Eliane Piaggio, Bertrand Bellier, Tim Sparwasser, David Klatzmann, Hugo D. Luján
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-08265-9

Internet

https://doi.org/10.1038/s41467-018-08265-9

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