Observation of high-temperature macromolecular confinement in lyophilised protein formulations using terahertz spectroscopy

Observation of high-temperature macromolecular confinement in lyophilised protein formulations using terahertz spectroscopy

Characterising the structural dynamics of proteins and the effects of excipients are critical for optimising the design of formulations. In this work we investigated four lyophilised formulations containing bovine serum albumin (BSA) and three formulations containing a monoclonal antibody (mAb, here...

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Bibliographic Details
Main Authors: Talia A. Shmool, P.J. Woodhams, Markus Leutzsch, Amberley D. Stephens, Mario U. Gaimann, Michael D. Mantle, Gabriele S. Kaminski Schierle, Christopher F. van der Walle, J. Axel Zeitler
Format: Article
Language:English
Published: Elsevier 2019-12-01
Series:International Journal of Pharmaceutics: X
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156719300362

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http://www.sciencedirect.com/science/article/pii/S2590156719300362

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