Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7.

Bacterial killing by complement requires direct anchoring of membrane attack complex precursor C5b-7.

An important effector function of the human complement system is to directly kill Gram-negative bacteria via Membrane Attack Complex (MAC) pores. MAC pores are assembled when surface-bound convertase enzymes convert C5 into C5b, which together with C6, C7, C8 and multiple copies of C9 forms a transm...

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Bibliographic Details
Main Authors: Dennis J Doorduijn, Bart W Bardoel, Dani A C Heesterbeek, Maartje Ruyken, Georgina Benn, Edward S Parsons, Bart W Hoogenboom, Suzan H M Rooijakkers
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-06-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1008606

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https://doi.org/10.1371/journal.ppat.1008606

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