Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation

Hox11 genes regulate postnatal longitudinal bone growth and growth plate proliferation

Hox genes are critical regulators of skeletal development and Hox9-13 paralogs, specifically, are necessary for appendicular development along the proximal to distal axis. Loss of function of both Hoxa11 and Hoxd11 results in severe malformation of the forelimb zeugopod. In the radius and ulna of th...

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Bibliographic Details
Main Authors: Kyriel M. Pineault, Ilea T. Swinehart, Kayla N. Garthus, Edward Ho, Qing Yao, Ernestina Schipani, Kenneth M. Kozloff, Deneen M. Wellik
Format: Article
Language:English
Published: The Company of Biologists 2015-11-01
Series:Biology Open
Subjects:
Hox genes
Growth plate
Chondrocyte
Postnatal skeletal development
Online Access:http://bio.biologists.org/content/4/11/1538

Internet

http://bio.biologists.org/content/4/11/1538

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