Widespread aggregation of mutant VAPB associated with ALS does not cause motor neuron degeneration or modulate mutant SOD1 aggregation and toxicity in mice

<p>Abstract</p> <p>Background</p> <p>A proline-to-serine substitution at position-56 (P56S) of vesicle-associated membrane protein-associated protein B (VAPB) causes a form of dominantly inherited motor neuron disease (MND), including typical and atypical amyotrophic la...

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Bibliographic Details
Main Authors: Qiu Linghua, Qiao Tao, Beers Melissa, Tan Weijia, Wang Hongyan, Yang Bin, Xu Zuoshang
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Molecular Neurodegeneration
Subjects:
ALS
Online Access:http://www.molecularneurodegeneration.com/content/8/1/1