Using cell membrane chromatography and HPLC-TOF/MS method for in vivo study of active components from roots of Aconitum carmichaeli

An offline two-dimensional system combining a rat cardiac muscle cell membrane chromatography time-of-flight mass spectrometry (CMC-TOF/MS) with a high Performance liquid chromatography time-of-flight mass spectrometry (HPLC-TOF/MS) was established for investigating the parent components and metabol...

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Bibliographic Details
Main Authors: Yan Cao, Xiao-Fei Chen, Di-Ya Lü, Xin Dong, Guo-Qing Zhang, Yi-Feng Chai
Format: Article
Language:English
Published: Elsevier 2011-05-01
Series:Journal of Pharmaceutical Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177911700223