Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Impact of global PTP1B deficiency on the gut barrier permeability during NASH in mice

Objective: Non-alcoholic steatohepatitis (NASH) is characterized by a robust pro-inflammatory component at both hepatic and systemic levels together with a disease-specific gut microbiome signature. Protein tyrosine phosphatase 1 B (PTP1B) plays distinct roles in non-immune and immune cells, in the...

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Main Authors: Carmen Rubio, Marta Puerto, Juan J. García-Rodríquez, Van B. Lu, Irma García-Martínez, Rosa Alén, Patricia Sanmartín-Salinas, M. Val Toledo-Lobo, Jorge Saiz, Javier Ruperez, Coral Barbas, Luis Menchén, Fiona M. Gribble, Frank Reimann, Luis G. Guijarro, Jose M. Carrascosa, Ángela M. Valverde
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Molecular Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877820300260

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http://www.sciencedirect.com/science/article/pii/S2212877820300260

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