Combination of G-CSF and AMD3100 Improves the Anti-inflammatory Effect of Mesenchymal Stem Cells on Inducing M2 Polarization of Macrophages Through NF-κB-IL1RA Signaling Pathway

Combination of G-CSF and AMD3100 Improves the Anti-inflammatory Effect of Mesenchymal Stem Cells on Inducing M2 Polarization of Macrophages Through NF-κB-IL1RA Signaling Pathway

Mobilized peripheral blood-derived mesenchymal stem cells (PB-MSCs) mainly derived from bone marrow-derived MSCs (BM-MSCs) exert a similar anti-inflammatory effect. However, the mechanism of anti-inflammatory effect of mobilized PB-MSCs by a combination of G-CSF and AMD3100 remains unclear. Cultured...

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Bibliographic Details
Main Authors: Long Chen, Qian Zhang, Qin-Hua Chen, Feng-Yin Ran, Li-Mei Yu, Xiu Liu, Qiang Fu, Gong-Yu Song, Jun-Ming Tang, Tao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Pharmacology
Subjects:
peripheral blood-derived mesenchymal stem cells
anti-inflammatory
macrophage
polarization
IL1rn
NF-κB
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00579/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.00579/full

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