Enantiomeric characterization and structure elucidation of Otamixaban

Enantiomeric characterization and structure elucidation of Otamixaban

Otamixaban is a potent (Ki=0.5 nM) fXa inhibitor currently in late-stage clinical development at Sanofi for the management of acute coronary syndrome. Being unproductive in obtaining a suitable crystal of Otamixaban, the required enantiomeric characterization has been accomplished using vibrational...

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Bibliographic Details
Main Authors: Jian Shen, Jiping Yang, Winfried Heyse, Harald Schweitzer, Norbert Nagel, Doris Andert, Chengyue Zhu, Vincent Morrison, Gregory A. Nemeth, Teng-Man Chen, Zhicheng Zhao, Timothy A. Ayers, Yong-Mi Choi
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Journal of Pharmaceutical Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177913001081

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http://www.sciencedirect.com/science/article/pii/S2095177913001081

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