The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis

Abstract Background The molecular chaperone TRAP1, the mitochondrial isoform of cytosolic HSP90, remains poorly understood with respect to its pivotal role in the regulation of mitochondrial metabolism. Most studies have found it to be an inhibitor of mitochondrial oxidative phosphorylation (OXPHOS)...

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Main Authors: Abhinav Joshi, Li Dai, Yanxin Liu, Jungsoon Lee, Nastaran Mohammadi Ghahhari, Gregory Segala, Kristin Beebe, Lisa M. Jenkins, Gaelyn C. Lyons, Lilia Bernasconi, Francis T. F. Tsai, David A. Agard, Len Neckers, Didier Picard
Format: Article
Language:English
Published: BMC 2020-01-01
Series:BMC Biology
Subjects:
HSP90
TRAP1
Oxidative phosphorylation
Glutamine
Mitochondria
Molecular chaperone
Online Access:https://doi.org/10.1186/s12915-020-0740-7

Internet

https://doi.org/10.1186/s12915-020-0740-7

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