Computational Design of Epitope-Specific Functional Antibodies

Computational Design of Epitope-Specific Functional Antibodies

Summary: The ultimate goal of protein design is to introduce new biological activity. We propose a computational approach for designing functional antibodies by focusing on functional epitopes, integrating large-scale statistical analysis with multiple structural models. Machine learning is used to...

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Bibliographic Details
Main Authors: Guy Nimrod, Sharon Fischman, Mark Austin, Asael Herman, Feenagh Keyes, Olga Leiderman, David Hargreaves, Marek Strajbl, Jason Breed, Shelley Klompus, Kevin Minton, Jennifer Spooner, Andrew Buchanan, Tristan J. Vaughan, Yanay Ofran
Format: Article
Language:English
Published: Elsevier 2018-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124718316851

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http://www.sciencedirect.com/science/article/pii/S2211124718316851

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