Phosphoproteomic Profiling of Rat’s Dorsal Root Ganglia Reveals mTOR as a Potential Target in Bone Cancer Pain and Electro-Acupuncture’s Analgesia

Phosphoproteomic Profiling of Rat’s Dorsal Root Ganglia Reveals mTOR as a Potential Target in Bone Cancer Pain and Electro-Acupuncture’s Analgesia

Bone cancer pain (BCP) is a clinical refractory mixed pain involving neuropathic and inflammatory pain, with the underlying mechanisms remaining largely unknown. Electro-acupuncture (EA) can partly alleviate BCP according to previous research. We aim to explore the proteins and major pathways involv...

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Bibliographic Details
Main Authors: Wen Wang, You Zhou, Yangqian Cai, Sisi Wang, Fangbing Shao, Junying Du, Junfan Fang, Jinggen Liu, Xiaomei Shao, Boyi Liu, Jianqiao Fang, Yi Liang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
proteomic profiling
protein microarray
mTOR
bone cancer pain
mechanism
electro-acupuncture
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.593043/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.593043/full

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