Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury

Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury

Objective: Promotion of endogenous β-cell mass expansion could facilitate regeneration in patients with diabetes. We discovered that the secreted protein CTGF (aka CCN2) promotes adult β-cell replication and mass regeneration after injury via increasing β-cell immaturity and shortening the replicati...

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Bibliographic Details
Main Authors: Kimberly G. Riley, Raymond C. Pasek, Matthew F. Maulis, Jennifer C. Dunn, W. Reid Bolus, Peggy L. Kendall, Alyssa H. Hasty, Maureen Gannon
Format: Article
Language:English
Published: Elsevier 2015-08-01
Series:Molecular Metabolism
Subjects:
CTGF
β-cell
Proliferation
Regeneration
Macrophages
T-cells
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877815000915

Internet

http://www.sciencedirect.com/science/article/pii/S2212877815000915

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