Potential Broad Spectrum Inhibitors of the Coronavirus 3CLpro: A Virtual Screening and Structure-Based Drug Design Study

Potential Broad Spectrum Inhibitors of the Coronavirus 3CLpro: A Virtual Screening and Structure-Based Drug Design Study

Human coronaviruses represent a significant disease burden; however, there is currently no antiviral strategy to combat infection. The outbreak of severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory syndrome (MERS) less than 10 years later demonstrates the potential of coron...

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Bibliographic Details
Main Authors: Michael Berry, Burtram C. Fielding, Junaid Gamieldien
Format: Article
Language:English
Published: MDPI AG 2015-12-01
Series:Viruses
Subjects:
human coronaviruses
molecular docking
3CLpro
virtual screening
structure-based drug design
molecular dynamics
Online Access:http://www.mdpi.com/1999-4915/7/12/2963

Internet

http://www.mdpi.com/1999-4915/7/12/2963

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