Factor VIII-Fc Activates Natural Killer Cells via Fc-Mediated Interactions With CD16

Factor VIII-Fc Activates Natural Killer Cells via Fc-Mediated Interactions With CD16

The most challenging complication associated with Factor VIII (FVIII) replacement therapy is the development of neutralizing anti-drug antibodies, or inhibitors, which occur in 23-35% of severe (FVIII level <1%) hemophilia A (HA) patients and are a serious hindrance to effective management of...

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Bibliographic Details
Main Authors: H.A. Daniel Lagassé, Louis B. Hopkins, Wojciech Jankowski, Marc G. Jacquemin, Zuben E. Sauna, Basil Golding
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
Fc-fusion
immunogenicity
Fc gamma receptors
natural killer cells
antibody-dependent cellular cytotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.692157/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.692157/full

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