PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway

PCK1 Downregulation Promotes TXNRD1 Expression and Hepatoma Cell Growth via the Nrf2/Keap1 Pathway

Gluconeogenesis, generates glucose from small carbohydrate substrates, and drives the metabolic flux in parallel but opposite to glycolysis. The cytoplasmic isoform of phosphoenolpyruvate carboxykinase (PCK1 or PEPCK-C), a rate-limiting enzyme in gluconeogenesis, initiates the gluconeogenesis proces...

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Bibliographic Details
Main Authors: Lin Tuo, Jin Xiang, Xuanming Pan, Qingzhu Gao, Guiji Zhang, Yi Yang, Li Liang, Jie Xia, Kai Wang, Ni Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Oncology
Subjects:
phosphoenolpyruvate carboxylase kinase 1
thioredoxin reductase 1
hepatocellular carcinoma
reactive oxygen species
nuclear factor erythroid 2-related factor 2
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2018.00611/full

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https://www.frontiersin.org/article/10.3389/fonc.2018.00611/full

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