Effect of Microencapsulation Shear Stress on the Structural Integrity and Biological Activity of a Model Monoclonal Antibody, Trastuzumab

Effect of Microencapsulation Shear Stress on the Structural Integrity and Biological Activity of a Model Monoclonal Antibody, Trastuzumab

The aim of the present study was to investigate the influence of process shear stressors on the stability of a model monoclonal antibody, trastuzumab. Trastuzumab, at concentrations of 0.4–4.0 mg/mL, was subjected to sonication, freeze-thaw, lyophilisation, spray drying and was encapsulated into mic...

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Bibliographic Details
Main Authors: Ritesh M. Pabari, Benedict Ryan, Catherine McCarthy, Zebunnissa Ramtoola
Format: Article
Language:English
Published: MDPI AG 2011-08-01
Series:Pharmaceutics
Subjects:
trastuzumab
shear stress
stability
size exclusion chromatography
circular dichroism
biological activity
Online Access:http://www.mdpi.com/1999-4923/3/3/510/

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http://www.mdpi.com/1999-4923/3/3/510/

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