Phosphodiesterase 3 mediates cross-talk between the protein kinase- and cGMP- dependent pathways and cyclic AMP metabolism

 Phosphodiesterase 3 mediates cross-talk between the protein kinase- and cGMP- dependent pathways and cyclic AMP metabolism

 PDE3 is a dual-substrate phosphodiesterase responsible for hydrolyzing both cAMP and cGMP whilst being simultaneously inhibited by cGMP. This feature is related to presence of the 44 amino acid insert in the catalytic domain, which determines the mechanism of introduction of the cyclic nucleotide i...

Full description

Bibliographic Details
Main Authors: Edyta Makuch, Janusz Matuszyk
Format: Article
Language:English
Published: Index Copernicus International S.A. 2012-07-01
Series:Postępy Higieny i Medycyny Doświadczalnej
Subjects:
phosphodiesterase
PDE
structure and regulation of the activity of PDE3
protein kinase-dependent pathways
cAMP and cGMP signaling cross-talk
natriuretic peptide signaling
phosphodiesterase 3 family
PDE3A
Online Access:http://journals.indexcopernicus.com/fulltxt.php?ICID=1004074

Internet

http://journals.indexcopernicus.com/fulltxt.php?ICID=1004074

Similar Items