A general strategy to construct small molecule biosensors in eukaryotes

A general strategy to construct small molecule biosensors in eukaryotes

Biosensors for small molecules can be used in applications that range from metabolic engineering to orthogonal control of transcription. Here, we produce biosensors based on a ligand-binding domain (LBD) by using a method that, in principle, can be applied to any target molecule. The LBD is fused to...

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Bibliographic Details
Main Authors: Justin Feng, Benjamin W Jester, Christine E Tinberg, Daniel J Mandell, Mauricio S Antunes, Raj Chari, Kevin J Morey, Xavier Rios, June I Medford, George M Church, Stanley Fields, David Baker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2015-12-01
Series:eLife
Subjects:
biosensor
metabolic engineering
CRISPR
Online Access:https://elifesciences.org/articles/10606

Internet

https://elifesciences.org/articles/10606

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