A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients

A novel hotspot and rare somatic mutation p.A138V, at TP53 is associated with poor survival of pancreatic ductal and periampullary adenocarcinoma patients

Abstract Background Pancreatic Ductal Adenocarcinoma (PDAC) is a cancer of the exocrine pancreas and 5-year survival rates remain constant at 7%. Along with PDAC, Periampullary Adenocarcinoma (PAC) accounts for 0.5–2% of all gastrointestinal malignancies. Genomic observations were well concluded for...

Full description

Bibliographic Details
Main Authors: Gourab Saha, Richa Singh, Argha Mandal, Subrata Das, Esita Chattopadhyay, Prasun Panja, Paromita Roy, Navonil DeSarkar, Sumit Gulati, Supriyo Ghatak, Shibajyoti Ghosh, Sudeep Banerjee, Bidyut Roy, Saurabh Ghosh, Dipankar Chaudhuri, Neeraj Arora, Nidhan K. Biswas, Nilabja Sikdar
Format: Article
Language:English
Published: BMC 2020-06-01
Series:Molecular Medicine
Subjects:
Pancreatic ductal adenocarcinoma
Periampullary adenocarcinoma
Novel somatic hotspot mutation
Frequently mutated genes
Next generation sequencing
Online Access:http://link.springer.com/article/10.1186/s10020-020-00183-1

Internet

http://link.springer.com/article/10.1186/s10020-020-00183-1

Similar Items