Inhibition of Glycogen Synthase Kinase-3 in Androgen-Responsive Prostate Cancer Cell Lines: Are GSK Inhibitors Therapeutically Useful?

Inhibition of Glycogen Synthase Kinase-3 in Androgen-Responsive Prostate Cancer Cell Lines: Are GSK Inhibitors Therapeutically Useful?

The glycogen synthase kinase 3 (GSK-3) is a serine/threonine kinase widely expressed in mammalian tissues. Ini-tially identified by its ability to modulate glycogen synthesis, GSK-3 turned out to be a multifunctional enzyme, able to phosphorylate many proteins, including members of the steroid rece...

Full description

Bibliographic Details
Main Authors: Ludwig Rinnab, Stefanie V. Schütz, Jeannine Diesch, Evi Schmid, Rainer Küfer, Richard E. Hautmann, Klaus-Dieter Spindler, Marcus V. Cronauer
Format: Article
Language:English
Published: Elsevier 2008-06-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558608801510

Internet

http://www.sciencedirect.com/science/article/pii/S1476558608801510

Similar Items