A reference profile-free deconvolution method to infer cancer cell-intrinsic subtypes and tumor-type-specific stromal profiles

A reference profile-free deconvolution method to infer cancer cell-intrinsic subtypes and tumor-type-specific stromal profiles

Abstract Background Patient stratification based on molecular subtypes is an important strategy for cancer precision medicine. Deriving clinically informative cancer molecular subtypes from transcriptomic data generated on whole tumor tissue samples is a non-trivial task, especially given the variou...

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Bibliographic Details
Main Authors: Li Wang, Robert P. Sebra, John P. Sfakianos, Kimaada Allette, Wenhui Wang, Seungyeul Yoo, Nina Bhardwaj, Eric E. Schadt, Xin Yao, Matthew D. Galsky, Jun Zhu
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Genome Medicine
Subjects:
Deconvolution
Clustering
Bulk tumor profiling
Online Access:http://link.springer.com/article/10.1186/s13073-020-0720-0

Internet

http://link.springer.com/article/10.1186/s13073-020-0720-0

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