Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients

Endothelin receptor antagonists: effects on extracellular matrix synthesis in primary cultures of skin fibroblasts from systemic sclerosis patients

Endothelin-1 (ET-1) seems to enhance the pro-fibrotic protein synthesis by skin fibroblasts and its effects are mediated by endothelin-A and B (ETA and ETB) receptors. This study aimed to investigate the effects of ETA and ETB receptor antagonists (ETARA-sitaxentan and ETA/BRA-bosentan) on type I co...

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Bibliographic Details
Main Authors: B. Villaggio, B. Seriolo, A. Sulli, A. Parodio, C. Ferrone, R. Brizzolara, P. Montagna, S. Soldano, M. Cutolo
Format: Article
Language:English
Published: PAGEPress Publications 2012-12-01
Series:Reumatismo
Subjects:
skin fibrosis, endothelin receptor antagonist, endothelin-1, extracellular matrix proteins, fibroblasts, systemic sclerosis
Online Access:http://www.reumatismo.org/index.php/reuma/article/view/580

Internet

http://www.reumatismo.org/index.php/reuma/article/view/580

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