Comprehensive dissection of dispensable genomic regions in Streptomyces based on comparative analysis approach

Comprehensive dissection of dispensable genomic regions in Streptomyces based on comparative analysis approach

Abstract Background Large-scale genome reduction has been performed to significantly improve the performance of microbial chassis. Identification of the essential or dispensable genes is pivotal for genome reduction to avoid synthetic lethality. Here, taking Streptomyces as an example, we developed...

Full description

Bibliographic Details
Main Authors: Qing-Ting Bu, Yue-Ping Li, Huang Xie, Jue Wang, Zi-Yue Li, Xin-Ai Chen, Xu-Ming Mao, Yong-Quan Li
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Microbial Cell Factories
Subjects:
Genome reduction
Chassis
Synthetic lethality
Multi-omics
Essential genes
Streptomyces
Online Access:http://link.springer.com/article/10.1186/s12934-020-01359-4

Internet

http://link.springer.com/article/10.1186/s12934-020-01359-4

Similar Items