Dissecting the DNA binding landscape and gene regulatory network of p63 and p53

The transcription factor p53 is the best-known tumor suppressor, but its sibling p63 is a master regulator of epidermis development and a key oncogenic driver in squamous cell carcinomas (SCC). Despite multiple gene expression studies becoming available, the limited overlap of reported p63-dependent...

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Bibliographic Details
Main Authors: Konstantin Riege, Helene Kretzmer, Arne Sahm, Simon S McDade, Steve Hoffmann, Martin Fischer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
p63
p53
Online Access:https://elifesciences.org/articles/63266