Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis

Enoxacin extends lifespan of C. elegans by inhibiting miR-34-5p and promoting mitohormesis

Alterations in microRNA (miRNA) processing have been previously linked to aging. Here we used the small molecule enoxacin to pharmacologically interfere with miRNA biogenesis and study how it affects aging in C. elegans. Enoxacin extended worm lifespan and promoted survival under normal and oxidativ...

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Bibliographic Details
Main Authors: Silas Pinto, Vitor N. Sato, Evandro A. De-Souza, Rafael C. Ferraz, Henrique Camara, Ana Paula F. Pinca, Diego R. Mazzotti, Michael T. Lovci, Guilherme Tonon, Camila M. Lopes-Ramos, Raphael B. Parmigiani, Martin Wurtele, Katlin B. Massirer, Marcelo A. Mori
Format: Article
Language:English
Published: Elsevier 2018-09-01
Series:Redox Biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231718304646

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http://www.sciencedirect.com/science/article/pii/S2213231718304646

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