Immunoproteasome functions explained by divergence in cleavage specificity and regulation

Immunoproteasome functions explained by divergence in cleavage specificity and regulation

The immunoproteasome (iP) has been proposed to perform specialized roles in MHC class I antigen presentation, cytokine modulation, and T cell differentiation and has emerged as a promising therapeutic target for autoimmune disorders and cancer. However, divergence in function between the iP and the...

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Bibliographic Details
Main Authors: Michael B Winter, Florencia La Greca, Shirin Arastu-Kapur, Francesco Caiazza, Peter Cimermancic, Tonia J Buchholz, Janet L Anderl, Matthew Ravalin, Markus F Bohn, Andrej Sali, Anthony J O'Donoghue, Charles S Craik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-11-01
Series:eLife
Subjects:
proteasome
immunoproteasome
antigen presentation
proteostasis
Online Access:https://elifesciences.org/articles/27364

Internet

https://elifesciences.org/articles/27364

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