Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo

Caffeine citrate enhanced cisplatin antitumor effects in osteosarcoma and fibrosarcoma in vitro and in vivo

Abstract Background While multiagent chemotherapy has dramatically improved the prognosis of sarcoma, the novel chemotherapeutics have hardly developed over the past 30 years. Caffeine can induce apoptosis, delays in cell cycle progression and can enhance the cytocidal effects of anti-cancer agents....

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Bibliographic Details
Main Authors: Kensaku Abe, Norio Yamamoto, Katsuhiro Hayashi, Akihiko Takeuchi, Hiroyuki Tsuchiya
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Cancer
Subjects:
Caffeine citrate
Chemotherapy
Osteosarcoma
Fibrosarcoma
Cancer
Online Access:http://link.springer.com/article/10.1186/s12885-019-5891-y

Internet

http://link.springer.com/article/10.1186/s12885-019-5891-y

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