Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

Regulation of fibroblast Fas expression by soluble and mechanical pro-fibrotic stimuli

Abstract Background Fibroblast apoptosis is a critical component of normal repair and the acquisition of an apoptosis-resistant phenotype contributes to the pathogenesis of fibrotic repair. Fibroblasts from fibrotic lungs of humans and mice demonstrate resistance to apoptosis induced by Fas-ligand a...

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Bibliographic Details
Main Authors: Amos E. Dodi, Iyabode O. Ajayi, Christine Chang, Meghan Beard, Shanna L. Ashley, Steven K. Huang, Victor J. Thannickal, Daniel J. Tschumperlin, Thomas H. Sisson, Jeffrey C. Horowitz
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Respiratory Research
Subjects:
Fibrosis
Myofibroblast
Apoptosis
Extracellular matrix
Lung injury
Wound-repair
Online Access:http://link.springer.com/article/10.1186/s12931-018-0801-4

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http://link.springer.com/article/10.1186/s12931-018-0801-4

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