The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.

The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.

BACKGROUND: Acquired antibodies are important in human immunity to malaria, but key targets remain largely unknown. Plasmodium falciparum reticulocyte-binding-homologue-4 (PfRh4) is important for invasion of human erythrocytes and may therefore be a target of protective immunity. METHODS: IgG and Ig...

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Bibliographic Details
Main Authors: Linda Reiling, Jack S Richards, Freya J I Fowkes, Danny W Wilson, Watcharee Chokejindachai, Alyssa E Barry, Wai-Hong Tham, Janine Stubbs, Christine Langer, John Donelson, Pascal Michon, Livingstone Tavul, Brendan S Crabb, Peter M Siba, Alan F Cowman, Ivo Mueller, James G Beeson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3447948?pdf=render

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http://europepmc.org/articles/PMC3447948?pdf=render

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