Chk2-p53 and JNK in irradiation-induced cell death of hematopoietic progenitors and differentiated cells in Drosophila larval lymph gland

Chk2-p53 and JNK in irradiation-induced cell death of hematopoietic progenitors and differentiated cells in Drosophila larval lymph gland

Ionizing radiation (IR) induces DNA double-strand breaks that activate the DNA damage response (DDR), which leads to cell cycle arrest, senescence, or apoptotic cell death. Understanding the DDR of stem cells is critical to tissue homeostasis and the survival of the organism. Drosophila hematopoiesi...

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Bibliographic Details
Main Authors: Tram Thi Ngoc Nguyen, Jiwon Shim, Young-Han Song
Format: Article
Language:English
Published: The Company of Biologists 2021-08-01
Series:Biology Open
Subjects:
ionizing radiation
drosophila
hematopoietic progenitor
hematopoiesis
cell death
dna damage response
Online Access:http://bio.biologists.org/content/10/8/bio058809

Internet

http://bio.biologists.org/content/10/8/bio058809

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