Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.

Functional comparison of human adenomatous polyposis coli (APC) and APC-like in targeting beta-catenin for degradation.

Truncating mutations affect the adenomatous polyposis coli (APC) gene in most cases of colon cancer, resulting in the stabilization of β-catenin and uncontrolled cell proliferation. We show here that colon cancer cell lines express also the paralog APC-like (APCL or APC2). RNA interference revealed...

Full description

Bibliographic Details
Main Authors: Jean Schneikert, Shree Harsha Vijaya Chandra, Jan Gustav Ruppert, Suparna Ray, Eva Maria Wenzel, Jürgen Behrens
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3698177?pdf=render

Internet

http://europepmc.org/articles/PMC3698177?pdf=render

Similar Items