Dihydroartemisinin Inhibits the Proliferation of Esophageal Squamous Cell Carcinoma Partially by Targeting AKT1 and p70S6K

Dihydroartemisinin Inhibits the Proliferation of Esophageal Squamous Cell Carcinoma Partially by Targeting AKT1 and p70S6K

Dihydroartemisinin (DHA), a sesquiterpene lactone with endoperoxide bridge, is one of the derivatives of artemisinin. In addition to having good antimalarial properties, DHA exhibits anticancer effects including against malignant solid tumors. However, the mechanism by which DHA inhibits the progres...

Full description

Bibliographic Details
Main Authors: Lili Zhu, Xinhuan Chen, Yanyan Zhu, Jiace Qin, Tingting Niu, Yongwei Ding, Yang Xiao, Yanan Jiang, Kangdong Liu, Jing Lu, Wanjing Yang, Yan Qiao, Ge Jin, Junfen Ma, Ziming Dong, Jimin Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Pharmacology
Subjects:
esophageal squamous cell carcinoma
dihydroartemisinin
AKT1
mTOR
p70S6K
RPS6
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.587470/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.587470/full

Similar Items