Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

Products of vitamin D3 or 7-dehydrocholesterol metabolism by cytochrome P450scc show anti-leukemia effects, having low or absent calcemic activity.

Cytochrome P450scc metabolizes vitamin D3 to 20-hydroxyvitamin D3 (20(OH)D3) and 20,23(OH)(2)D3, as well as 1-hydroxyvitamin D3 to 1alpha,20-dihydroxyvitamin D3 (1,20(OH)(2)D3). It also cleaves the side chain of 7-dehydrocholesterol producing 7-dehydropregnenolone (7DHP), which can be transformed to...

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Bibliographic Details
Main Authors: Andrzej T Slominski, Zorica Janjetovic, Brian E Fuller, Michal A Zmijewski, Robert C Tuckey, Minh N Nguyen, Trevor Sweatman, Wei Li, Jordan Zjawiony, Duane Miller, Tai C Chen, Gerard Lozanski, Michael F Holick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-03-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2845617?pdf=render

Internet

http://europepmc.org/articles/PMC2845617?pdf=render

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