β-adrenergic receptor inhibition enhances oncolytic herpes virus propagation through STAT3 activation in gastric cancer

β-adrenergic receptor inhibition enhances oncolytic herpes virus propagation through STAT3 activation in gastric cancer

Abstract Background Oncolytic viruses (OVs) are considered a promising therapeutic alternative for cancer. However, OVs could activate the host innate immunity, then impair the viral propagation in tumor cells. In this study, we explored the effect of propranolol, a non-selective β-blocker, on the a...

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Bibliographic Details
Main Authors: Jiali Hu, Ruitao Lu, Yu Zhang, Wei Li, Qian Hu, Cuiyu Chen, Zhaoqian Liu, Wei Zhang, Ling Chen, Ran Xu, Jia Luo, Howard L. McLeod, Yijing He
Format: Article
Language:English
Published: BMC 2021-09-01
Series:Cell & Bioscience
Subjects:
Propranolol
Oncolytic virus
Gastric cancer
Innate immunity
Type I IFN signaling
Online Access:https://doi.org/10.1186/s13578-021-00687-1

Internet

https://doi.org/10.1186/s13578-021-00687-1

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