Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

Interleukin-10 inhibits interleukin-1β production and inflammasome activation of microglia in epileptic seizures

Abstract Background Microglia are important for secreting chemical mediators of inflammatory responses in the central nervous system. Interleukin (IL)-10 and IL-1β secreted by glial cells support neuronal functions, but the related mechanisms remain vague. Our goal was to demonstrate the efficacy of...

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Bibliographic Details
Main Authors: Yi Sun, Jiangjun Ma, Dongfang Li, Pinggan Li, Xiaolin Zhou, Yu Li, Zhanwen He, Lijun Qin, Liyang Liang, Xiangyang Luo
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Journal of Neuroinflammation
Subjects:
Epilepsy
Microglia
IL-10
IL-1β
Online Access:http://link.springer.com/article/10.1186/s12974-019-1452-1

Internet

http://link.springer.com/article/10.1186/s12974-019-1452-1

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