SPE–UPLC–MS/MS assay for determination of letrozole in human plasma and its application to bioequivalence study in healthy postmenopausal Indian women

SPE–UPLC–MS/MS assay for determination of letrozole in human plasma and its application to bioequivalence study in healthy postmenopausal Indian women

A rapid and sensitive ultra performance liquid chromatography–tandem mass spectrometry (UPLC–MS/MS) method is described for determination of letrozole in human plasma. Following solid phase extraction (SPE) of letrozole and letrozole-d4 on Orochem DVB-LP cartridges, chromatography was performed on A...

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Bibliographic Details
Main Authors: Pravin G. Vanol, Puran Singhal, Priyanka A. Shah, Jaivik V. Shah, Pranav S. Shrivastav, Mallika Sanyal
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Journal of Pharmaceutical Analysis
Subjects:
Letrozole
Letrozole-D4
UPLC–MS/MS
Solid phase extraction
Bioequivalence study
Online Access:http://www.sciencedirect.com/science/article/pii/S2095177916300508

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http://www.sciencedirect.com/science/article/pii/S2095177916300508

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