An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients

Narcolepsy is characterized by excessive daytime sleepiness (EDS), cataplexy, direct onsets of rapid eye movement (REM) sleep from wakefulness (DREMs) and deficiency of orexins, neuropeptides that promote wakefulness largely via activation of histamine (HA) pathways. The hypothesis that the orexin d...

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Bibliographic Details
Main Authors: Jian-Sheng Lin, Yves Dauvilliers, Isabelle Arnulf, Hélène Bastuji, Christelle Anaclet, Régis Parmentier, Laurence Kocher, Masashi Yanagisawa, Philippe Lehert, Xavier Ligneau, David Perrin, Philippe Robert, Michel Roux, Jeanne-Marie Lecomte, Jean-Charles Schwartz
Format: Article
Language:English
Published: Elsevier 2008-04-01
Series:Neurobiology of Disease
Subjects:
Narcolepsy
Sleep disorders
Histamine
Orexin
H3-receptor inverse agonist
Wakefulness
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996107002720

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http://www.sciencedirect.com/science/article/pii/S0969996107002720

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