Alpha-1-Antitrypsin Enhances Primary Human Macrophage Immunity Against Non-tuberculous Mycobacteria

Alpha-1-Antitrypsin Enhances Primary Human Macrophage Immunity Against Non-tuberculous Mycobacteria

Rationale: The association between non-tuberculous mycobacterial lung disease and alpha-1-antitrypsin (AAT) deficiency is likely due, in part, to underlying emphysema or bronchiectasis. But there is increasing evidence that AAT itself enhances host immunity against microbial pathogens and thus defic...

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Bibliographic Details
Main Authors: Xiyuan Bai, An Bai, Jennifer R. Honda, Charles Eichstaedt, Ariel Musheyev, Zhihong Feng, Gwen Huitt, Ronald Harbeck, Beata Kosmider, Robert A. Sandhaus, Edward D. Chan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
autophagy
mycobacteria
nuclear factor-kappa B
phagosome-lysosome fusion
serine protease inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01417/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.01417/full

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