MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells

MAP3K1 function is essential for cytoarchitecture of the mouse organ of Corti and survival of auditory hair cells

MAP3K1 is a serine/threonine kinase that is activated by a diverse set of stimuli and exerts its effect through various downstream effecter molecules, including JNK, ERK1/2 and p38. In humans, mutant alleles of MAP3K1 are associated with 46,XY sex reversal. Until recently, the only phenotype observe...

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Bibliographic Details
Main Authors: Rizwan Yousaf, Qinghang Meng, Robert B. Hufnagel, Ying Xia, Chandrakala Puligilla, Zubair M. Ahmed, Saima Riazuddin
Format: Article
Language:English
Published: The Company of Biologists 2015-12-01
Series:Disease Models & Mechanisms
Subjects:
Map3k1
Mekk1
Fgfr3
Fgf8
Fgf10
Hearing loss
Supernumerary outer hair cells
MAPK pathway
FGF signaling pathway
Online Access:http://dmm.biologists.org/content/8/12/1543

Internet

http://dmm.biologists.org/content/8/12/1543

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